Scientific documents library

Patients with acute coronary syndromes often have high immature platelet counts (IPF#) that the body produces to compensate for platelet loss caused by platelet aggregation due to atherosclerosis. This clinical information card explains the IPF# in this context and as it is a valuable supportive parameter for effective risk assessment and therapy management of coronary artery diseases.

The focus of this clinical information card is how the haematological parameter 'immature platelet fraction' (IPF) supports differential diagnosis of thrombocytopenia.

This poster includes information about bone marrow cytology and histology. As well as a table containing indications for bone marrow examination and decision criteria for bone marrow cytology or bone marrow histology. And finally images of normal bone marrow cytology.

This case report presents a patient who has undergone surgery for subarachnoid haemorrhage. A week after removal of the patient’s drainage tube, a check-up examination of CSF was performed. The CSF sample had a pale orange colour, so-called ‘xanthochromia’, which is caused by the presence of bilirubin, a degradation product of haemoglobin.

A patient case showing early detection of latent iron deficiency, that would not have been detected in a normal routine blood count or blood smear is described. A low RET-He (reticulocyte haemoglobin equivalent) value triggered a confirmatory test and lead to prompt treatment of the patient.

A blood count is part of almost every medical check-up and, as such, one of the most frequently ordered laboratory tests. Several research studies show how Extended Inflammation Parameters (EIP) can support infection diagnostics by measuring WBC immune cell activation from a CBC + DIFF.

In intensive care units, timely and accurate infection detection is vital for the appropriate treatment of critically ill patients. Sysmex haematology analysers can measure various cell activation parameters, providing valuable insights into the immune response activation. Nierhaus et al. established the concept of the Intensive Care Infection Score (ICIS RUO*) utilising Sysmex haematology parameters, including those that reflect cell activation, to assess the likelihood of infection in critically ill patients. Read the latest research about ICIS RUO* in this white paper. * RUO is the abbreviation for ‘Research Use Only’, which indicates that an in vitro diagnostic medical purpose has not been validated by the manufacturer. Health institutions that intend to use RUO product results for diagnostic purposes do so under their own responsibility and must observe the rules and regulations applicable in their region, such as Regulation (EU) 2017/746 (IVD-R) for the EU. Sysmex cannot support such diagnostic use.

It has been extensively described in the literature that samples from patients with unstable haemoglobin variants show a distinct pattern in the WDF scattergram. This SEED article focuses on how users can recognise these special patterns in the scattergrams.

For the sake of the patient - it is of critical importance that physicians and other healthcare personnel are able to confidently rely on laboratory test results in order to make meaningful and safe decisions about the diagnosis and treatment of patients entrusted to their care.